Pyrazole is a five-membered aromatic ring compound with the molecular formula C3H4N2. Learn how to prepare 1,3 pyrazole? full laboratory guide.
| Property | Value |
|---|---|
| Chemical Formula | C3H4N2 |
| Molecular Weight | 68.08 g/mol |
| Melting Point | 68-70°C |
| Boiling Point | 198-200°C |
| Density | 1.037 g/cm³ |
| Solubility in Water | Soluble |
| Solubility in Organic Solvents | Soluble in most organic solvents |
| Appearance | Colorless to pale yellow crystals |
| Odor | Odorless |
| Refractive Index | 1.548 (20°C) |
| pKa (Acid Dissociation Constant) | ~2.3 (pyrazole) |
| Flash Point | Not applicable |
| Autoignition Temperature | Not applicable |
1,3 pyrazole structure
It is a heterocyclic organic compound containing two carbon atoms and three nitrogen atoms in its ring structure. It is classified as an azole compound.
Requirement
- Ethyl acetoacetate
- Phenyl hydrazine
- Ether
- Ethanol
- Round bottom flask.
Theory
3-Methyl-1-phenyl pyrazole-5-one is synthesized by condensation of phenyl hydrazine and ethyl acetoacetate under basic condition.
1, 3 pyrazole synthesis
Procedure
- Heat a mixture of phenyl hydrazine (3.65 ml) and ethyl acetoacetate (4.9 ml) in a 250 ml round bottom flask on boiling water bath for 2 hours.
- Stir the reaction mixture with the help of a glass rod.
- Cool the reaction mixture and then add 20 ml ether with stirring.
- Filter the separated product, wash with ether and recrystallize with dilute ethanol (1:1).
- Melting point of the product is 127°C.
Result
The yield of obtained product was found to be……gm and percentage yield was…..% and melting point was found to be …… °C.
Uses: Using as intermediate in bulk drug industry.
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