Learn about implantable drug delivery system with their advantages and disadvantages. In 1861, Lafarge introduced the implantable system concept for sustained release drug administration.
What is implantable drug delivery system?
Implantable drug delivery systems are designed to be placed under the skin and release drugs into the blood circulation without repetitive insertion of needles.
Definition of IDDS is, it is a special drug delivery device designed to be implanted under the skin. It has a rod-shaped inner matrix made of polymer, forming a long body with two ends. The main feature is it has the capability to release drugs at a controlled manner over an extended period.
It was first introduced to produce steroid hormones containing solid implants for long-term delivery.
Ideal properties of IDDS
- Should stable in different environments.
- Should be compatible with the body.
- Should be easy to produce and sterilize.
- It should release drugs at a controlled rate.
- It reduces dosing frequency and improve patient compliance.
- Affordable for accessibility.
- Should be strong and durable.
- It should be free from surgical procedure.
What are the advantages of implantable drug delivery system?
- Needs minimal monitoring.
- It helps to get medication outside of hospital.
- Needs less dosing of medication.
- Improve patient compliance.
- Implants deliver drugs easily and smoothly, because it bypasses the barriers.
- Potential for controlled release of drug.
- Programmable pumps release drugs when its needed.
- It has great flexibility. Flexible implants control diverse drug types.
What are the disadvantages?
Here are some disadvantages of implantable drug delivery,
- Implants require a surgical process for insertion of device.
- Non-biodegradable implants need surgical removal after treatment ends.
- The device malfunctioning leads instant surgical removal of device.
- Only potent drugs can be used due to the small implant size.
- At implantation site, high drug concentration may cause adverse reactions.
Also read Principles of bioadhesion in mucosal drug delivery system. What is mucosal drug delivery system?