In novel drug delivery system, microencapsulation is a process where solids, liquids or even gases are enclosed within microscopic particles. These microparticles are solid particles with the size range of 1 to 1000 micrometers (µm). Learn definition, advantages and disadvantages.
How to define microparticles in ndds?
These are tiny solid particles or dispersed particles size ranging from 1 to 1000 micrometers (μm). These microparticles typically have a spherical shape and are made of polymers.
These microparticles can used as carriers for drugs. In a microparticle matrix, drug molecules can be dissolved, entrapped, encapsulated or attached. It provides uniform dispersion of drug molecules. This allows for controlled drug release and various pharmaceutical applications.
What are the advantages of microparticles?
- Increased drug bioavailability.
- Reduced local and systemic side effects.
- Hides unpleasant taste and odor of drugs.
- Provide protection from environmental factors.
- Prevent plasma drug concentration fluctuations.
- Microparticles improve powder flow.
- Enhance treatment efficiency and patient compliance.
- Increase chemical and physical storage stability for drugs and carriers.
- They utilize biodegradable lipids.
- Allow to incorporation of hydrophilic and hydrophobic drugs.
- Provide safe handling of toxic substances.
- Increase solubility of poorly soluble drugs.
- Provide targeted release of encapsulated drugs.
- Useful for various body parts.
- Application to various sites like eyes, lungs, and joints.
- Versatile in medical applications.
- Easy for patients who can’t chew.
- No harm to drug effectiveness.
Also read What is microencapsulation in NDDS?
What are the disadvantages?
- Higher production costs compared to standard formulations.
- Negative environmental impact due to polymer matrix degradation and by-products.
- Adverse effects from the degradation of polymer additives.
- Low reproducibility.
- Core material stability affected by process conditions.
- Environmental consequences and associated government registration costs.
- Uncertainty in securing government registration for products with potential environmental impact.
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- Disadvantages of microparticles:
- Costlier production compared to standard forms.
- Harmful environmental effects from polymer degradation.
- Negative impacts of polymer additives.
- Inconsistent results.
- Core material stability issues due to process conditions.
- Environmental concerns and registration costs.
- Uncertainty in gaining government approval for environmentally impactful products.
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- Microparticle disadvantages:
- Higher production costs.
- Environmental harm from polymer degradation.
- Issues with polymer additives.
- Inconsistent results.
- Core material stability problems.
- Environmental concerns and costs.
- Uncertain government approval for eco-impact products.