Learn how to prepare phenothiazine from diphenyl amine with its principle and procedure. Explore this full laboratory guide.
It is a heterocyclic organic compound. It consists of two benzene rings fused to a central sulfur-containing ring. Structure of phenothiazine is:
And its derivatives are used as antipsychotic medications, antiemetics and in the treatment of various medical conditions.
Preparation of phenothiazine from diphenyl amine
Firstly, for preparation these requirements are needed.
- Round bottom flask.
- Reflux condenser.
- Water bath.
- Oil bath.
- Diphenyl amine,
- Iodine.
- Ethanol.
- Charcoal.
Principle
When Diphenyl amine treated with Sulphur undergo fusion reaction in the presence of iodine to give phenothiazine, a tricyclic compound used as an antihistaminic agent.
Preparation procedure
- Fit a reflux condenser with a round bottom flask.
- Place 6.4 gm Sulphur, 16.8 gm of diphenyl amine and 300 mg iodine.
- Reflux the mixture on an oil bath at 190-200°C for 30-40 minutes.
- Cool and grind the residue mass.
- Now add 5 ml of ethanol and pinch of animal charcoal.
- Heat it until solid mass dissolves.
- Filter the solution while hot.
- Now cool the solution in ice bath.
- Again, filter the reaction mixture and you will obtain yellow crystals of phenothiazine. Melting point of the product is 184-185°C.
Now, calculate the percentage yield and theoretical yield:
After calculation submit the reports as:
The yield of obtained product was found to be ….. gm and percentage yield was ….% and melting point was found to be ……… °C.
Uses: Derivatives of phenothiazine are highly bioactive and have widespread uses like Promazine and Chlorpromazine as antipsychotic drugs.
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